Journal of Stem Cell Research & Therapy

Alan Mathew Punnoose

Publications

• Research Article
  Effect of glucose on the expression of CD24 marker in Umbilical-cord derived Mesenchymal Stem Cells
  Author(s): Rithika Rajendran, Febe Renjitha Suman, Alan Mathew Punnoose, Sarah Kuruvilla and S KrishnakumarRithika Rajendran, Febe Renjitha Suman, Alan Mathew Punnoose, Sarah Kuruvilla and S Krishnakumar
  
  A cluster of Differentiation 24 (CD24) is considered as a marker of pancreatic progenitor cells in the mouse. In human embryonic stem cells, CD24+ cells expressed Pancreatic Duodenal Homeobox 1 (PDX1) and insulin after 1-week culture. PDX1 is a transcription factor that is essential for pancreatic differentiation and beta cell maturation. These cells could provide a source for beta cell replacement. To define the proper culture conditions for Mesenchymal Stem Cells (MSCs) to differentiate into islet cells, the CD24 expression at the MSC level with various glucose concentrations may be helpful. This research aims to study the expression of CD24 in MSCs derived from umbilical cord Wharton’s jelly with varying concentrations of glucose in vitro. MSCs were isolated by enzymatic digestion using standard protocols from umbilical cord Wharton’s jelly with.. View More»
  DOI: 10.4172/2157-7633.1000444

  Abstract PDF