Pharmaceutica Analytica Acta

Abd El-Aziz H

Publications

• Research Article
  Spectrophotometric Methods for Simultaneous Determination of Rivaroxaban and Clopidogrel in Their Binary Mixture
  Author(s): Sharaf El-Din M, Ibrahim F, Shalan SH and Abd El-Aziz HSharaf El-Din M, Ibrahim F, Shalan SH and Abd El-Aziz H
  
  Three rapid, accurate and very simple derivative spectrophotometric methods for RIV and CLP assay in their binary mixture and tablet dosage forms were developed. Method (I) is first derivative spectrophotometric method, derivative amplitudes were measured at the zero crossing wavelength of 289 and 249.5 nm for estimation of RIV and CLP, respectively. The linearity is over the range 2.0 - 20.0 μg/ml for RIV and 5.0 - 60.0 μg/ml for CLP with LOD of 0.211 and 0.361 μg mL-1 and LOQ of 0.641 and 1.095 μg mL-1 for RIV and CLP, respectively. Method (II) is ratio derivative spectrophotometric method. The ratio spectra of each drug were derived by dividing its spectra on a constant concentration of the other drug as a divisor. Derivative amplitudes were measured at 256 nm for RIV and at 214.5 nm for CLP over the same linearity range as the first method with LOD of 0.137 and 0.485 &.. View More»
  DOI: 10.4172/2153-2435.1000575

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