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Abbas Ghaderi
Abbas Ghaderi
Shiraz Institute for Cancer Research,
PO BOX: 71345-1798, Shiraz
West Indies
Publications
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Research Article
Chemokines and Chemokine Receptors Expression in the Adipose Derived Stem Cells (ASCs), Breast Tissues and in Peripheral Blood of Patients with Breast Cancer
Author(s): Mahboobeh Razmkhah, Mansooreh Jaberipour and Abbas GhaderiMahboobeh Razmkhah, Mansooreh Jaberipour and Abbas Ghaderi
It has been demonstrated that the tumor angiogenic ability is one of the most important predictors of breast cancer progression. Factors controlling tumor angiogenesis are varied and currently under investigation. Chemokines, which produced by both tumor cells and cells of tumor microenvironment are known with a role in tumor angiogenesis. Here, we examined the expressions of SDF-1/CXCR4/CXCR7, CXCL13/CXCR5, RANTES/CCR5, MCP-1 and CCR7 in adipose derived stem cells (ASCs) and breast cancer tissues of breast cancer patients. Results of ASCs were compared to those from sex matched healthy individuals. Data of breast cancer tissues were compared between stage III and stages I and II tumors. As a result, SDF-1 protein showed higher expression in ASCs from patients with pathological stage III compared to those with pathological stages I and II tumors and normal individuals. In breast cance.. View More»
DOI: 10.4172/2157-2518.1000120