Gingival Fibromatosis (GF) is a slowly progressive, benign and rare disorder characterized by diffuse or local fibrous growth of gingiva. Hereditary Gingival Fibromatosis (HGF), which is usually an autosomal dominant trait, is the most common form. The attached gingiva, marginal gingiva and the interdental papilla is affected. In severe condition functional, periodontal, aesthetic and psychological problems may occur. Histopathology shows epithelial acanthosis and atypically abundant inflammatory infiltrates distributed in the sub-epithelial and connective tissue. The pathophysiology of gingival fibromatosis comprises excessive accumulation of extracellular matrix proteins. Mutation in the Son-of-Sevenless-1 (SOS-1) gene has been suggested as genetic attribute of hereditary gingival fibromatosis. To stabilize the long-term outcomes and alleviate suffering of adversely affected, non-surgical therapies and oral hygiene maintenance are important.
Published Date: 2022-06-24; Received Date: 2022-05-20