Gerontology & Geriatric Research

Abstract

The Gut-Brain Connection in Alzheimer's disease: Exploring the Role of Microbiota and Potential Therapies

Patricia Creole*

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and impaired daily functioning. While the exact mechanisms underlying AD remain elusive, there is a growing body of evidence suggesting that the gut-brain connection plays a crucial role in the development and progression of this disorder. The gut-brain axis refers to the bidirectional communication between the Central Nervous System (CNS) and the gastrointestinal tract, mediated by neural, hormonal, and immune pathways. Recent research has highlighted the influence of the gut microbiota on brain health and its potential implications for AD. This article delves into the intricate relationship between the gut microbiota and AD, explores the mechanisms through which the gut influences brain health, and discusses emerging therapeutic strategies targeting the gut-brain axis for AD treatment.

Published Date: 2023-08-28; Received Date: 2023-08-01