Pharmaceutica Analytica Acta

Abstract

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Malaz Osman Idress, Abdalla A. Elbashir and Omer Nur

Potentiometric determination of moxifloxacin (Moxi) by ion selective electrode based on ZnO nanorods incorporation with HPβ-CD as sensing ionophore and (KTFPB) potassium tetrakis- (3,5(triflouromethyl) phenyl borate ion as anionic site (additive) in polyvinyl chloride (PVC) membrane, without inner reference solution was developed. The sensor shows nearly nernstian response over a concentration range ( 5 × 10-8 M to 1 × 10-2 M) with a slope of 21.9 ± 0.16 mv decade-1 of concentration with a limit of detection (LOD) 0.127 μM. The electrode exhibits a fast dynamic response of 2 s for a period of 6 months without significant change in its characteristics with excellent stability and sensitivity toward inorganic species. The method is accurate and precise as indicated by the mean recoveries 99.5% with RSD less than 2%. The proposed method was successfully applied for the determination of Moxi in pure form and its pharmaceutical formulations.