Journal of Neonatal Biology

Abstract

Clinical Outcomes in One of Four Freeze to Thaw Embryos Transfer Protocols with GnRH Agonist Administration in the Luteal Phase: Retrospective Analysis

Mahmood Aamir*, Li Tang, Jie Zhang and Yan Li

Objectives: To determine if Gonadotropin Releasing Hormone (GnRH) agonist (triptorelin) administration supporting luteum phase in transferring Freeze to Thaw Embryos (FET) improves clinical outcomes.

Materials and methods: Analysis of a retrospective cohort and analyzed 3515 cycles of receiving FET at department of reproductive medicine of our hospital from February 2018 through December 2021.

The Patients were divided into GnRH-a (triptorelin+existing treatment) group and No GnRH-a (existing treatment without Triptorelin) group. There were 1033 and 2485 cases in above groups respectively. Live Births Rates (LBR) and Clinical Pregnancies Rates (CPR) were contrasted in two groups.

Results: We have found greater C.P.R (58.00% vs. 48.40%, P-value=0.003) and L.B.R (52.70% vs. 45.60%, P- value=0.001) for Hormone Replacement Therapy (HRT)-Freeze To Thaw Embryos Transfer (FET) cycles, and found no clinical significance for NC-FET (58.20% vs. 52.90%, P-value=0.364) and (54.40% vs. 47.00%, P-value=0.211), GnRH-a+HRT-FET (53.00% vs. 53.00%, P-value=0.176) and (46.20% vs. 47.30%, P-value=0.794), and Stimulation- FET (59.30% vs. 52.90% P-value=00.566) and (59.30% vs. 47.10%, P-value=00.247) in terms of CPR and LBR in two groups.

There was 47% increment of CPR in GnRH agonist group and there was 33% increment of L.B.R in same group.

Conclusion: During HRT-FET cycles, administering of Triptorelin 3-4 times in the existing luteal support can improve CPR and LBR. Administering Triptorelin during Luteal phase can prove new option for luteal support. Success rate of IVF in women of older age will increase significantly.

Published Date: 2023-10-18; Received Date: 2023-09-15