Journal of Aging Science

Abstract

Cell-type Specific Expression Changes in Aging and Alzheimer Disease

Lilach Soreq*

Aging is common to all human organisms. It is a risk factor for neurodegenerative diseases including Alzheimer’s Disease (AD). Global bulk gene expression profiling have previously suggested that the disease is governed by diverse transcriptional regulatory networks. Computational analysis of exon microarray/RNA-Seq data may enable detection of involved genes and pathways. Bioinformatic/statistical analyses may identify additional discrete glial, immune, neuronal and vascular cell populations spanning both AD and control post mortem brain samples. Notably, astrocytes and microglia cell gene markers have displayed the greatest transcriptomic impacts, with the induction of both shared and distinct gene program.

Published Date: 2023-06-13; Received Date: 2023-05-10