Journal of Clinical & Experimental Pharmacology

Abstract

A Thorough Overview of Polycystic Ovary Syndrome (PCOS) in Female Rats

Rutika Harshad*, Amruta Gaikwad, Sandeep Patil, Sudhir Patil, Pooja Khot, Aniket Borge

Among women of reproductive age, Polycystic Ovarian Syndrome (PCOS) is a common endocrine condition marked by polycystic ovaries, hyperandrogenism, and ovulatory failure. Numerous animal models, particularly rodent models like female rats, have been used to comprehend the pathophysiology and create therapeutic approaches. This study covers the features of female rat PCOS, induction techniques, applicability of the rat model to human PCOS, underlying processes, and treatment strategies evaluated in various animals. Hyperandrogenism, ovulatory dysfunction, and metabolic abnormalities are the hallmarks of PCOS, a prevalent and complex endocrine condition affecting women of reproductive age. Owing to the intricacy of PCOS, mouse models in particular have been developed to evaluate prospective treatments and gain a better understanding of the disease's aetiology. In order to replicate the many symptoms of PCOS, rodent models—especially those of rats and mice—are useful. This enables researchers to investigate hormonal, genetic, and metabolic causes. This article offers a thorough examination of the many rodent models of PCOS, including information on their induction techniques, benefits, drawbacks, and applicability to PCOS in humans.

Published Date: 2026-02-23; Received Date: 2024-12-30