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Whole exome sequencing reveals the landscape of clonal evolution from MDS/MPD to sAML progression
4th International Conference on Blood Malignancies & Treatment
April 18-19, 2016 Dubai, UAE
Hyeoung-Joon Kim
Chonnam National University, South Korea
Posters & Accepted Abstracts: J Blood Disord Transfus
Abstract:
In this study, we performed whole-exome sequencing on 39 patients at the time of MDS/MPD and sAML to dissect the mutational profiles and clonal evolution from MDS/MPD to sAML. Germline and tumor samples at the time of MDS/MPD and sAML were analyzed using whole exome sequencing (Agilent SureSelect v3, HiSeq 2000). Targeted sequencing for selected variants was performed to validate the result. Our extensive analyses reveal the order of gene mutations, inferring the hierarchy of mutated pathways during the progression. Also, our study shows that time series analysis contrasting MDS/MPD and sAML periods provides a much more comprehensive view of clonal structure and evolution.
Biography :
Email: hjoonk@chonnam.ac.kr