Journal of Vaccines & Vaccination

Vaccination coverage and compliance with three recommended schedules of 10-valent pneumococcal conjugate vaccine during the first year of its introduction in Brazil: A cross sectional study

10^th Euro Global Summit and Expo on Vaccines & Vaccination

June 16-18, 2016 Rome, Italy

Fabricia Oliveira Saraiva, Ruth Minamisava, Maria Aparecida da Silva Vieira, Ana Luiza Bierrenbach and Ana Lucia Andrade

Federal University of Goias, Brazil

Posters & Accepted Abstracts: J Vaccines Vaccin

Abstract:

Pneumococcal 10-valent conjugate vaccine (PCV10) was introduced to Brazil�??s National Immunization Program (NIP) in 2010. During the first year of vaccine introduction three schedules were used, corresponding to three different age groups: 3 primary doses+1 booster (for children aged �?�6 months); 2 doses+1 booster (7-11 months); a single dose (12-15 months). This study assessed vaccination coverage (percentage of children who completed the recommended number of doses) and compliance with recommended schedules (percentage of children who received all valid doses at the NIP recommended time interval). A household survey was conducted with 1,237 children, who were retroactively classified into one of three age groups, as a factor of the child�??s age relatively to 30 days after PCV10 introduction. Socioeconomic characteristics and vaccination dates were obtained. Adjusted prevalence ratios (PR) of variables independently associated with coverage and compliance were estimated by log binomial regression. Coverage of DTPHib was used for comparison purposes. Overall, vaccination coverage was 54.6% (95% CI 52.1-57.7%), lower than DTP-Hib coverage (93.0%; 95% CI 91.5-94.3%). Compliance with recommended schedules was 16.8% (95% CI: 14.7-18.6%). Children 7-11 months old had lower coverage (40.7%) and compliance (6.3%) compared to children aged 12-15 months (coverage: 88.8%; compliance: 35.6%) and �?�6 months old (coverage: 54%; compliance: 18.8%). Having private health insurance was associated with higher PCV10 coverage (PR=1.25; 95% CI: 1.06-1.47, p=0.007) and compliance (PR=1.09; 95% CI: 1.02-1.16, p=0.015). Although PCV10 coverage rapidly increased shortly after vaccination introduction, it was not matched by compliance with recommended schedules.

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