Journal of Dermatitis

The role of Fibulin-3 in non-melanoma skin cancer of Egyptian patients: Case control immunohistochemical study

22^nd World Dermatology Congress

September 27-28, 2021 | Webinar

Taghreed A. El-Sayed

Menoufi a University, Egypt

Scientific Tracks Abstracts: J Dermatitis

Abstract:

Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) were categorized as nonmelanoma skin cancers. Fibulin-3 is involved in the development of different tumors; however, its role in cSCC and BCC remains unknown. we recently evaluated the role of fi bulin-3 in BCC and cSCC and its relation to the available demographic, clinical and pathological data.The current study included 17 patients of BCC, 17 patients of SCC and 17age and sex matched healthy volunteer as a control group, attending to Dermatology and Plastic Surgery clinics at Menoufi a University Hospital during the period between May 2019 and February 2020. We founded that Fibulin-3 expression was signifi cantly downregulated in cSCC and BCC tissues compared with normal skin (p1=0.018), Furthermore, there was signifi cant difference between fi bulin-3 expression in SCC and BCC groups and the degree of apoptosis (p value = 0.029 and <0.001 respectively) and between fi bulin-3 intensity of expression and grade in SCC group (P value = 0.008). The results indicate that decreased fi bulin-3 expression in cSCC and BCC was associated with decreased apoptosis of tumor cells thus increasing their proliferation and migration, so fi bulin-3 agonist might be of benefi t for cSCC and BCC patients.

Biography :

Taghreed A. El-Sayed has completed her M.B.B.Ch at the age of 25 years from Faculty of medicine – Menoufi a University, Egypt. She is working resident dermatology at Egyptian ministry of health.