Journal of Pharmacovigilance

The importance of chemistry in pharmacovigilance

9^th International Conference and Exhibition on Pharmacovigilance & Drug Safety

July 17-18, 2017 Munich, Germany

Helianildes Silva Ferreira

Instituto de Química da Universidade Federal da Bahia, Brazil

Posters & Accepted Abstracts: J Pharmacovigil

Abstract:

Pharmacovigilance in Brazil has been increased and regulated since the 1960�??s. A lot of efforts have been made to monitor and control the quality of medicines as well as effectiveness and to report the effects in the human being, especially in the group of children, pregnant and elders. Researchers have reported that this group is more vulnerable to the medicines, especially because of the sensibility to the side effects of them. But what is the relationship between chemistry and it? What are the main mechanisms that could decrease or increase the medicine effects in the human body? Let�??s begin from the start; chemistry is one of the sciences that help pharmacovigilance to achieve its objective and to answer to some valuable questions: What is the decay time of the active substance in the body? What are the reactions that take place when you use another medicine at the same time (medicines interactions)? What is the transport phenomenon that allows the substance to flow in and out of the organisms? Pharmacokinetics and pharmacodynamics for sure will help to answer those questions, as well as the chemistry that involves the reactions rates, thermodynamic equilibrium, and adsorption and desorption processes, diffusion rates and so on. The result of those complex reactions (pharmacokinetics) and transport phenomena (pharmacodynamics) inside the body will show the effectiveness of the drug, the adverse reactions and events caused by the drug quality, the un-appropriated therapy, unusual purposes, intoxications and so on.

Biography :

Email: helianildes@ufba.br