Health Care : Current Reviews

THE EFFECTS OF MAGNESIUM PRETREATMENT ON REPERFUSION INJURY AFTER CABG SURGERY

8^th World Congress on Healthcare & Medical Tourism

November 17-18, 2016 | Dubai UAE

Mostafa kamal Abdellatif

Ain Shams University, Egypt

Posters & Accepted Abstracts: Health Care: Current Reviews

Abstract:

Background: Myocardial ischemia/reperfusion injury is a complex phenomenon that leads to organ dysfunction and failure following CABG. Data from numerous animal experiments and clinical trials suggest that magnesium, a physiologic calcium blocker, may be efficacious for reduction of reperfusion injury. Aim of the work: We investigated whether an intravenous administration of magnesium before reperfusion can decrease IR injury after CABG with cardiopulmonary bypass. Methods: forty patients undergoing CABG were randomly assigned to a MG group (n = 20) or an NS group (n = 20). The MG groups received 25 mg/kg of MgSO4 mixed in 100 ml normal saline intravenously before reperfusion and the NS groups received an equal volume of normal saline. The levels of lactate and pH, were measured to assess reperfusion injury at three specific times, which were before induction and after declamping by 10 min and 30 min. To evaluate postoperative other organ dysfunction, alanine aminotransferase (ALT), and creatinine levels were measured at postoperative day 0. Results: The blood lactate levels were significantly lower at 10 and 30 min after reperfusion in the MG groups compared to the NS groups. In addition, postoperative alanine aminotransferase (ALT) was significantly higher in the NS group than MG group. Conclusions: Magnesium administration before reperfusion of heart in CABG with cardiopulmonary bypass significantly reduces blood lactate levels. These findings suggest that magnesium treatment may have protective effects on IR injury.

Biography :

Email: mostafa_2041980@yahoo.com