Journal of Bioequivalence & Bioavailability

The effect of mucoadhesive polymers in improving drug bioavailability & absorption

10^th World Congress on Bioavailability and Bioequivalence

April 08-09, 2019 Abu Dhabi, UAE

Amal Ahmed Abdel Nabbi Hassan

Dubai Pharmacy College, UAE

Scientific Tracks Abstracts: J Bioequiv Availab

Abstract:

The oral mucosa offers an interesting site for the application of dosage forms that release drugs within/ throughout the oral mucosa, by assuring a high drug bioavailability for topic and systemic effects. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. In addition to factors related to the oral mucosa and oral environment features, the physical-chemical characteristics of mucoadhesive polymers must be also considered as factors influencing the mucoadhesive bonds. The study was conducted to formulate different types of MDDS, using mucoadhesive polymers (e.g. carbopols, sodium alginate, chitosan) and have been utilized in different dosage forms in efforts to achieve systemic delivery of drugs through different mucosal membranes.

Conclusion: Since a sustained drug release can be guaranteed only if dosage forms remain in contact with the oral site of absorption/application for a prolonged time, the development of mucoadhesive dosage forms is mandatory. They can prolong the residence time of the dosage form at the site of absorption thus enhance drug therapeutic efficacy.

Biography :

Amal Ahmed Abdel Nabbi Hassan is working in Dubai Pharmacy College, Dubai, UAE. She has teaching research experience and high communication skills. She has been serving as an OCM and participating in many international conferences.

E-mail: amalahmed1222@gmail.com