Journal of Stem Cell Research & Therapy

The effect of Anethum on Dyrk1B gene expression in metabolic syndrome and coronary artery disease

7^th International Conference and Exhibition on Cell and Gene Therapy

March 15-16, 2018 | London, UK

Maryam Fathi

Arsanjan university, Iran

Posters & Accepted Abstracts: J Stem Cell Res Ther

Abstract:

Introduction: Cardiovascular disease (CVD) is one of the main causes of death in the world. Metabolic syndrome is known as insulin resistance syndrome, which leads to atherosclerosis and coronary artery diseases. One of the most important genes that may be involved in metabolic syndrome is Dyrk1B. In this study, we used Anethum in metabolic syndrome by studying the gene expression of Dyrk1B. Anethum has been proven to reduce fat and cholesterol. Methods: First, we extracted the RNA from differentiated mesenchymal cells and drug treated mesenchymal cells. Using realtime PCR method, were measured the Dyrk1B gene expression. Results were analyzed with One-way ANOVA method. Results: Expression was Dyrk1B when subjected to differentiation, 4.34 fold increases (pvalue=0.0062). It was also shown that Dyrk1B expression in differentiated cell groups treated with anethum decreased gene expression compare differentiated cell group alone. (Differentiation: 4.343, Anethum 1: 1.838, Anethum 2: 1.064). Discussion: Anethum has been proven to reduce fat and cholesterol. This study Anethum reduced .

Biography :

Maryam Fathi is pursuing her MS in Genetics. She has done a research on Dyrk1B gene and medicinal plants. She has worked in a genetic counseling center for a while. She has also done a project on Liver Transplantation as a part of her BS Degree.
Email:maryamfathi1369@gmail.com