Journal of Blood Disorders & Transfusion

Testosterone therapy interacts with previously undiagnosed familial thrombophilia, facilitating development of osteonecrosis

3^rd International Conference on Hematology & Blood Disorders

November 02-04, 2015 Atlanta, USA

Domonique Smith

Jewish Hospital, USA

Posters-Accepted Abstracts: J Blood Disord Transfus

Abstract:

Idiopathic osteonecrosis (ON) (not secondary to high dose long term corticosteroids, alcoholism, fracture-dislocation, etc.) can be caused by osseous venous occlusion leading to increased osseous venous pressure, reduced arterial influx and ischemic necrosis. Although not widely recognized; familial thrombophilia is commonly pathoetiologic for the development of ON. In this study, we examined the interaction between testosterone treatment (TT) and previously undiagnosed thrombophilia facilitating the development of ON in 12 men and 4 women who developed idiopathic ON 6 months (median) after starting TT. When TT is given to patients with previously undiagnosed familial thrombophilia, ON commonly occurs, particularly in the presence of Factor V Leiden heterozygosity. Elevation of (E2) derived from the aromatization of testosterone interacts with thrombophilia to promote development of ON. Screening for common familial thrombophilias prior to starting TT is a tool to optimize estimation of the benefit/risk ratio of TT.

Biography :

Email: smithdqs@yahoo.com