Modern Chemistry & Applications

Synthesis, structural characterization and anti-diabetic activities of organotin(IV) azo-carboxylates: Crystal structure of a 48 membered macrocyclic-tetrameric trimethyltin(IV) complex

International Conference on Applied Chemistry

October 17-18, 2016 Houston, USA

Keisham Surjit Singh, Manojit Roy, Subhadip Roy, Janmoni Kalita and S Suresh Kumar Singh

National Institute of Technology Agartala, India
North Eastern Regional Institute of Science & Technology, India

Scientific Tracks Abstracts: Mod Chem appl

Abstract:

Triorganotin(IV) complexes of azo-carboxylic acids were synthesized by the reaction of 2/4-(2,4-dihydroxy-phenylazo)- benzoic acids with appropriate triorganotin(IV) chlorides [R= Me for compounds Me3SnH2L1 and Me3SnH2L2; Ph for compounds Ph3SnH2L1 and Ph3SnH2L2 and Bu for compound Bu3SnH2L2] in presence of triethylamine. The characterization of the complexes was accomplished by elemental analyses, UV, IR and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Structure of Me3SnH2L2 was established by X-ray crystal structure analysis. X-ray crystal structure of Me3SnH2L2 revealed that the compound exhibits a 48 membered macrocyclic-tetrameric structure with trigonal bipyramidal geometry around the tin atoms in which the three methyl groups occupy the equatorial positions while the apical positions are being occupied by the oxygen atom of carboxylate group of one ligand and the phenoxide oxygen atom of another ligand. All the complexes display a sharp singlet 119Sn resonance in the range specified for the four coordinate structures suggesting that complexes have tetrahedral structures in solution. The five coordinate structure of the complexes in solid state dissociated into monomeric species with four coordinate structures in solution. Anti-diabetic activities of the complexes were studied and the results showed that the synthesized compounds exhibited effective activity even higher than the standard compound acarbose.

Biography :

Keisham Surjit Singh has completed his PhD from North Eastern Hill University, Shillong, India and then joined as Lecturer in the Department of Chemistry, NERIST, Arunachal Pradesh, India. In 2010, he joined as Assistant Professor in National Institute of Technology, Agartala, India. He has published more than 20 papers in reputed journals like New Journal of Chemistry, Inorganica Chimica Acta, Journal of Organometallic Chemistry, etc. He acts as reviewer for Medicial Chemistry Research, Complex Metals, etc., and has been serving as an Editorial Board Member of International Journal of Scientific and Engineering Research.

Email: surjitkeisham@yahoo.co.in