Journal of Bioequivalence & Bioavailability

Synthesis of Naproxen molecular clusters by super-critical CO₂ processing

10^th World Congress on Bioavailability and Bioequivalence

April 08-09, 2019 Abu Dhabi, UAE

Sudhir Kumar Sharma

New York University Abu Dhabi, UAE

Scientific Tracks Abstracts: J Bioequiv Availab

Abstract:

In pharmaceutical industry, poor water solubility and limited bioavailability has a major concern on new drug development. It is well established that the bioavailability of such drugs can be improved by reducing their particle size. A number of conventional strategies are available in literature for particle size reduction but they suffer with some disadvantages and handling concerns. Recently, supercritical CO₂ (sc-CO₂) based processes are found to be more promising for micronization of pharmaceuticals as they have successfully addressed the above concerns and offer additional advantages like economic, non-toxic, scalable, environmentally compatible and etc. In present studies, we report the synthesis of naproxen molecular clusters via supercritical CO₂ drug formulation. These molecular clusters were collected in a special designed a two-stage collection vessel, cooled to liquid N₂temperatures, resulted embedding of drug molecular clusters in‘dry ice’. Gradual transferring of the ‘dry ice’ into deionized water, resulted in the true solubilization of drug molecular clusters. Afterword’s, these solutions were drop-casted on silicon substrate and dried for overnight under ambient conditions, resulted in a stable, viscous films with liquid like behavior. Analytical characterizations showed that these solutions have retained their chemical and structural identity after sc-CO₂processing. This is interesting to note that raw naproxen powder is solid powder under ambient conditions with melting points of 154o C. Our observations are expected to explore the sc-CO₂ processing strategy for other existing drug formulations and would open up new drug delivery platforms.

Biography :

Sudhir Kumar Sharma has completed his Masters in Physics and MTech in Materials from Department of Physics, Barkatullah University Bhopal, India. He has completed his PhD from the Indian Institute of Science Bangalore, India. He as a Post-doctratral Fellow attended Centre for Nano Science and Engineering (CeNSE), IISc. Bangalore, India. He has worked as a Research Associate at New York University Abu Dhabi, UAE and is currently working as a Research Scientist. He has more than 90 international journals and conferences publications.

E-mail: sudhir.sharma@nyu.edu