Modern Chemistry & Applications

Synthesis and characterization of supramolecules and their application as a chemosensor for drugs

9^th Global Chemistry Congress

July 23-24, 2018 | Lisbon, Portugal

Kiramat Shah

University of Swat, Pakistan

Posters & Accepted Abstracts: Mod Chem Appl

Abstract:

The monitoring of pharmaceutical drugs in the environment is of great importance worldwide. For example, in Karachi, Pakistan due to contaminated water, six children died and about 200 fell ill in 2005. A large number of pharmaceutical drugs in highly alarming amount were found in different components of drinking water (surface water, drainage, and effluent) of Karachi in the microgram-per-liter range during bioassay directed chemical analysis. The photophysical evaluation of supramolecular organic molecules as optical probes for detection of water toxins has been recognized to be very selective, sensitive, and economical as compared to the previously used methodologies. Synthesis, characterization and molecular recognition properties of fluorene based supramolecular cleft is reported. The cleft molecule was prepared in a single-step with good yield (85% yield), by linking fluorene with 1-ethyl piperazine. The cleft molecule was carefully characterized using various spectroscopic techniques such as NMR and mass spectrometry. The supramolecular interaction of cleft with amoxicillin, 6APA, aspirin, captopril, cefotaxime, ceftriaxone, cefuroxime, diclofenac, penicillin, and cephradine was evaluated by fluorescent spectroscopy. The molecular recognition studies showed that amoxicillin selectively binds with cleft in the presence of other drugs. The analytical method developed for the supramolecular interaction of molecular cleft and amoxicillin was validated at varying pH, concentration and temperature during recognition process. Job's plots indicated that the stochiometry of the interactions between the cleft and the amoxicillin was 1:1.

Biography :

E-mail: kiramat4s@gmail.com