Journal of Bioequivalence & Bioavailability

Synthesis and characterization of 2-((4R,4aR,5aS,6S)-1,3-Dioxo-3,3a,4,4a,5,5a,6,6a- Octahydro-4,6- Ethenocyclopropa[Æ?]Isoindol-2(1H)-yl)-N-( Substituted Phenyl) Acetamides anticepted to have anti HIV-1 activity

2^nd International Conference & Expo on Biopharmaceutics and Biologic Drugs

September 14-16, 2016 San Antonio, USA

Abdulmajeed S H Alsamarrai

University of Samarra, Iraq

Posters & Accepted Abstracts: J Bioequiv Availab

Abstract:

This work includes the synthesis of some new octahydro 2-((4R,4aR,5aS,6S)-1,3-dioxo-3,3a,4,4a,5,5a,6,6a-o-4,6- ethenocyclopropa[�?]isoindol-2(1H)-yl)-N-( substituted phenyl) acetamides (3-11) by reaction of (4R,4aR,5aS,6S)-4,4a,5,5a,6,6ahexahydro- 4,6- ethenocyclopropa[�?] isoindole-1,3(2H,3aH)-dione (1) with 2-chloro-N-(substituted phenyl) acetamides (2) in the presence of potassium carbonate in refluxing acetonitrile as a solvent. These compounds have been identified by using spectroscopic methods including IR,1H-NMR, 13C-NMR and elemental analysis (CHN).

Biography :

Abdulmajeed S H Alsamarrai has completed his PhD from University of Birmingham, UK, in 1984. He was the Dean of the college of applied science, University of Samarra, Iraq before that he was the Dean of the college of education, University of Tikret, Iraq. He has published more than 30 papers in reputed journals inside and outside Iraq.

Email: abdulmajeedsalihhamad@yahoo.com