Journal of Pharmacovigilance

Synthesis and biological studies of new anti-inflammatory agents based NSAID core structures

Conference Series LLC Joint International Event on 7^th Pharmacovigilance & Pharmaceutical Industry

August 22-24, 2016 Vienna, Austria

Shaaban K Mohamed

Manchester Metropolitan University, UK

Posters & Accepted Abstracts: J Pharmacovigil

Abstract:

Historically, no doubt, the ancient Egyptians, since 2000 BC, were the first to use salicylate rich plants, or what is so called later as Aspirin, to reduce fevers. This natural aspirin extract was used till late 18th century and was first synthesized in 1853. This led to discovery of many other non-steroidal anti-inflammatory drugs (NSAIDs) based acetic or acidic functional group such as Ibuprofen, Indomethacin, Naproxcin, etc. On long term administration, NSAIDs showed serious adverse reaction mainly as gastro-intestinal (GI) incidences. In this study, we try to overcome such undesired side effects by modifying the chemical structures of such drugs.

Biography :

Email: shaabankamel@yahoo.com