Journal of Liver

Suggested function of Tabebuia avellanedae extract on alcoholic fatty liver disease

3^rd World Congress on Hepatitis and Liver Diseases

October 10-12, 2016 Dubai, UAE

Hyunji Lee, Youngeun Hong, So Hee Kwon, Jongsun Park and Jisoo Park

Chungnam National University, South Korea
Yonsei University, South Korea

Posters & Accepted Abstracts: J Liver

Abstract:

Alcohol-induced liver injury is the most common liver disease in which fatty acid metabolism is altered. It is thought that altered NAD+/NADH redox potential by alcohol in the liver cause fatty liver by inhibiting fatty acid oxidation and the activity of tricarboxylic acid cycle reactions. Tabebuia avellanedae extract (TAE), a naturally occurring quinone, has been shown to stimulate fatty acid oxidation in an obese mouse model by activating adenosine monophosphate-activated protein kinase (AMPK). In this report, we clearly show that TAE reduced alcohol-induced hepatic steatosis and induced fatty acid oxidizing capacity in ethanol-fed rats. TAE treatment markedly decreased hepatic lipids while serum levels of lipids and lipoproteins were increased in rats fed ethanol-containing liquid diets with TAE administration. Furthermore, inhibition of lipolysis, enhancement of lipid mobilization to mitochondria and up-regulation of mitochondrial β-oxidation activity in soleus muscle were observed in ethanol/TAE-treated animals compared to the ethanol-fed rats.

Biography :

Hyunji Lee is currently pursuing Masters at the Metabolic Disease and Cellular Signaling Laboratory, Department of Pharmacology and Medical Science, College of Medicine, Chungnam National University, South Korea. She has recently published her first paper in "Clinical Interventions in Aging".

Email: dlguswl1602@gmail.com