Journal of Microbial & Biochemical Technology

Study the possible seropositivity connection of EBV, rubella virus & CMV infection with four groups of autoimmune diseases in sample of Iraqi patients

International Conference and Summit on Industrial & Pharmaceutical Microbiology

October 17-18, 2016 Kuala Lumpur, Malaysia

Jasim Mohammed Muhsin

Middle Technical University, Iraq

Posters & Accepted Abstracts: J Microb Biochem Technol

Abstract:

Background: Autoimmune diseases are complex and occurs when the immune system attacks host tissue for unknown etiology or maybe by some other genetic factors or environmental triggers (mainly viruses, bacteria and other infectious microorganisms; by acting as a major cofactors and serving as important initiators in the disease progression for a specific autoimmune sickness and not causing illness on their own) or even as complications or opportunistic infections associated with the disease. Aims: The present study aimed to discuss the evidence linking certain infectious agents (viruses) to autoimmune diseases in humans, to determine the possible roles of some studied clinico-pathological factors like gender, age and to investigate the prevalence of seropositivity of the antibodies titers of EBV, rubella virus, CMV with autoimmune diseases development in humans. Patients & Methods: In this study, four groups candidates of celiac diseases (CD) n=31, diabetes mellitus-I (DM-I) n=30, rheumatoid arthritis (RA) n=30 & systemic lupus erythematosus (SLE) n=30 were studied from 1st-30th of January 2016 at Medical City, Baghdad. Demographic and laboratory data were collected. All the samples were examined for the presence of EBV VCA-IgG, rubella IgG, CMV IgM by indirect ELISA techniques by using a commercial kits from Diagnostic Automations Co., USA. Results: A total of 121 autoimmune disease patients were studied, the overall positive results for EBV VCA IgG was 68.6% while for rubella IgG was 50.4% and for CMV IgG was 52.1% with significant differences in comparing with the negative results (p<0.05). Celiac disease and diabetic type-I patients had been detected with high seropositivity for EBV VCA IgG as 32.5% for each of them, while the high positive results of rubella IgG was detected in celiac disease patients as 32.8%. Finally, the diabetic type-I patients showed the most high seropositivity for CMV IgG as 33.3% in significant differences with the negative results regarding to all the other positive ones (p<0.05). Conclusion: Our data support an association of the presence of autoimmune diseases with viral infection by the high level of viruses�?? seropositivity that had been detected. In addition, this study proposes that viruses have the ability to trigger autoimmunity through molecular mimicry and their adjuvant effects during initiation of disease.

Biography :

Email: jasim.muhsin99@gmail.com