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Solubility and dissolution rate enhancement of lornoxicam by formulating solid dispersions using spray drying technique
3rd World Congress Bioavailability & Bioequivalence
March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India
Ajit A. Patil, Sunita S. Shinde, Sanjay P. Boldhane and John I. Disouza
Posters: J Bioequiv Availab
Abstract:
T he aim of the present study was to prepare and characterize solid dispersions of water insoluble non-steroidal anti- inflammatory drug, Lornoxicam (LOX), using different polymeric surfactants like Plasdone-S630, Lutrol-F68 and Soluplus for enhancing the solubility and dissolution of the drug. Solid dispersions were prepared by spray drying technique at 1:1, 1:2 and 1:3 drug to polymer ratios respectively. Furthermore, the solubility and the dissolution rate of drug in its different solid dispersion systems were explored and solid dispersion system which showed faster dissolution rate and maximum solubility, has selected for further characterizations. Techniques like, (DSC), (FTIR) and (SEM) were used to examine the physical state and chemical interactions between drug and polymer. Among all prepared Solid dispersion systems, the system which contain?s 1:3 ratio of drug and Plasdone-S630, has shown seven fold increases in solubility than pure LOX and complete drug release within ten minutes.DSC thermograms showed significant broad and horizontal melting endotherm of the LOX when prepared as solid dispersion, instead of sharp melting endotherm at 230-232 ☐ C for pure crystalline drug. This indicates, there is change from crystalline to amorphous form for all ratios of LOX and Plasdone-S630. From FTIR depiction it has observed that there are chances of interactions between the N-H and carbonyl groups of LOX with the ester group of Plasdone-S630 because of shifting in the positions of respective spectra?s. Finally, we concluded that dissolution rate and solubility of the LOX has increased significantly at ratio 1:3 for LOX and plasdone-S630.