Journal of Pharmacovigilance

Sleep disorders related to antidepressant drug use

4^th International Conference and Exhibition on Pharmacovigilance & Clinical Trials

August 10-12, 2015 London, UK

Farhan Ahmad Khan, Kirti Vishwakarma, Vishal P Giri and Chitrak Bansal

Posters-Accepted Abstracts: J Pharmacovigilance

Abstract:

Background: Prescription of antidepressants has been increased from the last decade. Also, they are responsible for producing so many ADRs such as dry mouth, blurred vision, weight gain and drowsiness, sleep disorders. Sleep disorders can generally be divided into 3 large groups: (1) Insomnia, (2) those with a primary complaint of daytime sleepiness, and (3) those associated with disruptive behaviors during sleep?the disorders of arousal. So, active surveillance is needed to access these ADRs. Aim & Objective: To analyze the sleep disturbances as an adverse drug reaction (ADRs) of various antidepressants prescribed to the patients attending the Psychiatry OPD at Teerthanker Mahaveer Medical College & Research Centre. Materials & Methods: The data were collected from the Red ADR boxes in the department of Psychiatry OPD at TMMC & RC, Moradabad, U.P. The patients, who were prescribed antidepressant drugs for duration of 10 months (Dec, 2013- July, 2014) were included in the study. Results: Total number of patients enrolled on the basis of inclusion and exclusion criteria = 50 Total number of ADRs=65. Total no of patients with sleep disturbances as ADRs=28 Conclusion: The drug most frequently implicated to cause sleep disturbances was Mirtazapine. Increased sleep was the commonest ADR found to occur. Unusual ADRs such as sleep talking was also seen. However, we assume that more robust reporting is needed as this shall enable us to detect the category of sleep disturbance, based on polysomnography.