Memon Z1, Shah A2 and Devrajani B1
Scientific Tracks Abstracts: J Bacteriol Parasitol
Background: Tuberculosis (TB) is a curable disease though it is still remains a major public health problem worldwide
especially in developing countries. TB ranks as the second leading cause of death throughout the world. Pakistan ranked as
fourth in the midst of 22 elevated challenging tuberculosis nations. Trace elements have involved in many biochemical and
physiological functions.Poor concentration of trace elements has been resulting clinical outcome.
Objectives: The objective of study was to find out the alteration in serum trace elements levels in active pulmonary tuberculosis
patients and was compared it with normal healthy volunteers with no sign and symptoms of TB.
Method: A total of 248 active pulmonary tuberculosis patients were selected from Liaquat University of Medical & Health
Sciences, Jamshoro, Sindh, Pakistan, Liaquat University Hospital, Hyderabad, Sindh, Pakistan, Rajputana Hospital, Hyderabad,
Sindh, Pakistan and Institute of Chest Diseases, kotri, Sindh, Pakistan. The subjects were recruited from both genders with
same age group 20-70 of years. Blood samples of active pulmonary tuberculosis patients with sputum smear positive were
collected and were compared with healthy control subjects without symptoms of pulmonary tuberculosis.Approval was taken
from all hospitals. Informed consent was also taken from each patients and healthy participants. Serum trace element analysis
was carried out by flame atomic absorption spectrophotometer (FAAS).
Results: Among248 active pulmonary tuberculosis patients, 104(42%) was male patients while144(58%) was female subjects
respectively.The interpretation of outcome was made on the basis of reference ranges. In our study we were found that the
mean serum zinc, iron and magnesiumwere significantly low inactive pulmonary tuberculosis patients (58.1 mg/dl), (34.2 mg/
dl) and (0.6 mg/dl). While mean serum calcium waselevated compare to normal healthy control subjects.
Zainab Manzoor Memon Ph.D. Research Scholar in Biochemistry. Presently she is working at Liaquat University of Medical & Health Sciences, Jamshoro,
Pakistan. She has eight international research publications and presented her research work at national and international conferences. She has attended many
academic workshops, symposium and has three years research experience. She has expertise on bio analytical techniques such as AAS, Spectrophotometer, AAA,
Ultra Centrifuge Machine, HPLC, Microlab 300 & Chemistry Analyzer. She also has command on statistical software including SPSS and Minitab.