Journal of Vaccines & Vaccination

Serotype distribution and Penicillin resistance of Streptococcus pneumoniae in Kuwait: A ten-year study of impact of pneumococcal conjugate vaccines

7^th Middle East - Global Summit and Expo on Vaccines & Vaccination

September 28-29, 2015 Dubai, UAE

Mokaddas E and Albert M J

Kuwait University, Kuwait

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Introduction & Objectives: The pneumococcal conjugate vaccine-7 (PCV-7) was introduced in Kuwait in August 2006 and PCV-13 in August 2010 for children less than 2 years. The study is done to evaluate the impact of PCV7 and PCV13 on serotype distribution and antimicrobial resistance of invasive S. pneumoniae isolates. Methods: The study included all cases of invasive pneumococcal disease (IPD) divided into two periods. The pre-vaccination period is from August 2003 to July 2006 and the post-vaccination period is from August 2006 to July 2013. Serotyping and Penicillin susceptibility testing are done using Quellung reaction and Etest method respectively. Results: There are 63 invasive isolates, 25% from children â?¤5 years and 156 invasive isolates, 28% from children â?¤5 years in the pre and post vaccination periods respectively. In the pre vaccination period, PCV-7 and PCV-13 vaccine coverage in all age groups and in children <5 years is 50% and 70% respectively. In the post-vaccination period, the vaccine coverage in all age groups and in children <5 years is 21%, 29% for PCV-7 and 46% and 51% for PCV-13. The drop in vaccine serotypes and the increase in the non-vaccine serotypes during post vaccination period compared to pre vaccination period are statistically significant (p value 0.001). Penicillin resistance among S. pneumoniae isolates dropped from 67.9% in pre vaccination period to 46.2% in post vaccination period (p value 0.006). Conclusion: After 7 years of PCV use in Kuwait, new emerging serotypes of S. pneumoniae are seen.

Biography :

Email: e.mokaddas@HSC.EDU.KW