Journal of Vaccines & Vaccination

Role of insulin like growth factor-1 derived from macrophages in an influenza vaccine induced humoral immune response

10^th Euro Global Summit and Expo on Vaccines & Vaccination

June 16-18, 2016 Rome, Italy

Jae-Hwan Nam

Catholic University of Korea, South Korea

Posters & Accepted Abstracts: J Vaccines Vaccin

Abstract:

It is known that vaccination is required to induce the production of antigen specific effector and memory immune cells. This process involves various growth hormones and cytokines. Among them, insulin-like growth factor-1 (IGF-1), derived from macrophages, plays important roles in immune functions as well as in cellular metabolism. Based on previous studies, we investigated the correlation between macrophage induced IGF-1 and the production of vaccine mediated effector/memory immune cells using macrophage derived IGF-1 gene knockout (MIKO) mice. Wild-type (WT) control and MIKO mice were immunized twice with influenza virus vaccine at an interval of 3 weeks. The titers of influenza specific antibody induced by the vaccine were checked 2 weeks after the first vaccination. The titers were significantly lower in vaccinated MIKO mice than in vaccinated WT mice from 1 week after the second immunization, which means that the MIKO mice did not show any boost in the effect of the vaccine. Moreover, the populations of CD138+B220+ antibody secreting B-cells were lower in MIKO mice than in WT mice with or without vaccine treatment. Therefore, the low antibody titers might be caused by a reduction in the production of antibody secreting B-cells in MIKO mice. Taken together, although we could not identify the mechanism, these results suggest that macrophage derived IGF-1 might play a role in the functions of vaccine activated effector B cells.

Biography :

Jae-Hwan Nam is currently a Professor of the Department of Biotechnology at the Catholic University of Korea. He has received his PhD from the Department of Biology at Korea University and has worked as a Senior Research Scientist at the KNIH and as Postdoctoral Researcher at the NIAID, NIH. He has researched about vaccine, viral vector systems; virus induced signal pathways and more recently about virus induced obesity. He has published more than 100 scientific articles and has been serving as an Editorial Board Member of International Journal of Obesity, Journal of Bacteriology and Virology and Clinical and Experimental Vaccine Research.

Email: jhnam@catholic.ac.kr