Journal of Vaccines & Vaccination

Risk factor analysis among Trimethoprim- Sulfamethoxazole resistant Escherichia coli isolates

International Conference & Exhibition on Vaccines & Vaccination

22-24 Nov 2011 Philadelphia Airport Marriott, USA

Rashid Ramazanzadeh and Majid Mansouri

Accepted Abstracts: J Vaccines Vaccin

Abstract:

Background : Ttrimethoprim-sulfamethoxazole (TMP-SMX) can be used for treatments of several infection including respiratory tract infections, renal and urinary tract infections, gastrointestinal tract infections, skin and wound infections, septicemias and other infections caused by sensitive organisms. Objectives: Th e aim of this study was to evaluate risk factors for acquisition of TMP-SMX resistance in E. coli strains among hospitalized patients, in a university hospital of Sanandaj- Iran. Methods: Th e study type was case-control. A case patient was defi ned as a patient who had one isolate of TMP-SMX resistance E. coli strain. A control patient was defi ned as a patient who had one isolate of TMP-SMX sensitive E. coli strain. TMP-SMX resistance was determined by using of disk diff usion methods. Results: Out of 343 total isolates, 197 (57.43%) were TMP-SMX resistance. Th e use of ventilator was a risk for acquisition of TMP-SMX resistance isolate (odds ratio [OR] = 3.037, [95% CI] =1.60 to 5.75, P< 0.000). Th e use of catheter was a risk for acquisition of TMP-SMX resistance isolate (odds ratio [OR] =2.93, [95% CI] =1.15 to 7.43, P< 0.013). Th ere was signifi cant correlation between days of stay in ward and TMP-SMX resistance (p < 0.003). Conclusions: Th e main risk factors associated for TMP-SMX resistance were use of ventilator, use of catheter and days of stay in ward. Th ere is need more study to evaluate the role of this factor in order to control the spread of drug resistance.