Journal of Dermatitis

RGPAV Resistin gene polymorphism in acne vulgaris. Does It Have an association?

22^nd World Dermatology Congress

September 27-28, 2021 | Webinar

Taghreed Ahmed Abdel Wahab

Menoufi a University, Egypt

Scientific Tracks Abstracts: J Dermatitis

Abstract:

Background: Acne vulgaris is a skin disease that infl ames the sebaceous gland with multiple etiologic agents. Many pro-infl ammatory adipokines contribute to this pathogenesis. Resistin is one of them, which acts as a proinfl ammatory mediator that activates kappa B, a nuclear factor, and c-Jun N-terminal kinases pathways inducing toll-like receptor-2, interleukin-1, 6, and Tumor Necrosis Factor Alpha (TNF- α). The Resistin gene affects the promoter and intron regions’ polymorphisms’ expression levels. Aim of the work: This study aims to study the association of Resistin gene polymorphisms (RETN -420 C/G) and the development of acne vulgaris in Egyptian patients and whether it is associated with serum Resistin’s levels and disease severity. Subjects and Methods: Resistin (RETN) gene (rs1862513) genotypes were identifi ed using the technique of Restriction Fragment Length Polymorphism (RFLP) and serum resistin presence was assessed by enzyme-linked immunosorbent assay in 40 patients suffering from acne vulgaris with 40 age- and sex-matched healthy control subjects as a cross-reference. Patients were divided into mild, moderate, and severe groups. The GAGS (Global Acne Grading System) was used to assess the severity of patients’ acne. Results: CG and GG genotypes were immensely present in cases (P = 0.006) OR1= 4.43 CI 95% (1.53–12.7) and OR2 = 5.47 CI 95% (0.99–30.1) where G-allele statistically dominated in the patient group where P = 0.001 and OR= 3.57 CI 95% (1.63–7.80). Also, a positive signifi cant relationship between RETN genotypes and serum Resistin levels and GAGS score was present. Conclusion: RETN genes rs1862513 GG and G allele are correlated to the development and severity of acne vulgaris in a sample of the Egyptian population

Biography :

Taghred Ahmed has completed her MB.BCH, at the age of 25 years from Menoufi a University, EGYPT and passed fi rst & second parts of Master degree of Dermatology, Andrology & STD from Menoufi a University faculty of Medicine. she is General Practitioner in Health Sector, Dermatology Resident in Berket Al Sabaa General Hospital Menoufi a Governorate EGYPT, previous position General Pracitioner in health care center.