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Recombinant mycobacterium heat shock protein-70 (rHSP- 70) TLR-2, TLR-4 agonist as a perspective tool for protection against bacterial and viral infections and tumors in mice
International Conference & Exhibition on Vaccines & Vaccination
22-24 Nov 2011 Philadelphia Airport Marriott, USA
Vorobiev D.S., Semenova I.B
Scientific Tracks Abstracts: J Vaccines Vaccin
Abstract:
Agonists of TLRs are considered as tools for therapy from diff erent diseases including infections and tumors. Th e purpose of our work was to estimate the capacity of rHSP-70 to protect mice against Salmonella enterica Serovar Typhimurium and infl uence virus H5N2 and to decrease tumor growth (melanoma B16). We established that the rHSP-70 induced short- time 50% protection from S. Typhimurium and infl uence virus H5N2 aft er single injected doses 100 μg/mice and 400 μg/mice. 3-times inoculation 10 μg/mice of rHSP-70 was led to long-time protection against S. Typhimurium. At 21st day (the follow up period) from 50% to 80% mice were alive. 20 μg and 100 μg of rHSP-70 injected to C57Bl/6 mice induced inhibition of tumor growth (melanoma B16) on 65% and 30% respectively at 21st day. Next we demonstrated that the rHSP-70 enhances expression of CD25 and CD56 on membrane of mononuclear leukocytes from peripheral blood of healthy donors but not aff ect expression of CD4 and CD16. Th e rising expression of CD25 and CD56 indicated the increase of natural killers and active lymphocytes in the population of lymphocytes. In the present study was shown resistance to bacterial and viral infections and antitumor activity in mice. We suggest that the rHSP-70 may be a candidate for creation of vaccines against multiple pathogens and anticancer tool.
Biography :
Dr. Denis Vorobiev has completed his Ph.D at the age of 28 years from Mechnikov Research Institute for Vaccine and Sera (Moscow, Russia) in 2009. At present time he is the scienti fi c worker of Mechnikov Research Institute for Vaccine and Sera. He has published 10 articles