Journal of Blood Disorders & Transfusion

RBC profile in chronic kidney disease

6^th International Conference on Hematology

October 03-05, 2016 Orlando, USA

Sushma Belurkar

Kasturba Medical College, India

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Objective: To analyze changes in various RBC parameters in patients with CKD. Methods: This is a retrospective study conducted for a period of 2 and ½ years. Total 300 cases of CKD were evaluated and their RBC parameters were studied. Results: Various RBC parameters in CKD patients. The mean RBC count in these patients was 3.29±0.8�?1012/L (Normal: 4.6±0.6�?1012/L), mean Hemoglobin (Hb) was 93±50 g/L (Normal: 135±20 g/L), PCV was 0.28±0.08 L/L (Normal: 0.40±0.05 L/L), Mean cell volume was 86±7 fl (Normal: 86±9 fl), Mean cell Hb was 28.4±2.6 pg (Normal: 29±4 pg) and Mean cell Hb count was 328±17 g/L (Normal: 340±30 g/L). The major hematological abnormality in CKD patients was anemia with 67% of cases having Hb value below 10 gm/dl and the degree of anemia worsened with the stage of the disease. Deviation in Hb levels is directly proportional to RBC count and hematochrit. But there was non-significant change in the MCV, MCH and MCHC values indicating normocytic normochromic type of anemia. Only 3.4% cases had microcytic hypochromic anemia and 2.6% cases had macrocytic anemia. Features of hemolysis were seen in 21% cases. Conclusion: Chronic kidney disease is often complicated by anemia and the major causes of anemia are failure of renal erythropoietin secretion and anemia of chronic disease. Other factors causing anemia include chronic blood loss, hemolysis, bone marrow suppression, inflammatory factors and vitamin deficiencies.

Biography :

Email: sushbelur@gmail.com