Journal of Psychiatry

Rare variants in neurotrophin receptor substrates are potential risk alleles in the etiology of schizophrenia

2^nd International Conference on Psychiatry and Psychiatric Disorders

May 02-04, 2016 Chicago, Illinois, USA

Moses V Chao

NYU School of Medicine, USA

Posters & Accepted Abstracts: J Psychiatry

Abstract:

Impaired signal transduction pathways are considered to contribute to the etiology of schizophrenia. However, components of trophic factor signaling have not been considered even though neurotrophins such as BDNF are crucially involved in neurodevelopment and synaptic connectivity. Here we describe new de novo mis-sense mutations in ARMS/Kidins220 and TRIO genes in exome sequencing a cohort of unrelated and ethnically diverse schizophrenia-affected subjects. The two genes gave the highest genetic burden among the neurotrophin pathway genes and are highly expressed in cortex and hippocampus. These two genes are of particular interest since they are downstream of BDNF and are involved in spine formation, synaptic plasticity and dendrite formation and growth cone collapse. The ARMS/Kidins220 protein is tyrosine phosphorylated by Trk and ephrin receptors and not by other growth factor receptors. TRIO is a scaffold protein, which associates with ARMS/Kidins220 and forms a ternary complex with SorCS2 and p75, which leads to growth cone collapse. Hence, this exome analysis suggested that the two scaffold proteins, ARMS/Kidins220 and TRIO, act in the neurotrophin pathway to regulate morphological changes.

Biography :

Email: moses.chao@med.nyu.edu