Health Care : Current Reviews

Production and applications of microbial polyhydroxyalkanoates as drug delivery systems

Joint Event on International Conference on Applied Microbiology and Microbial Biotechnology & International Conference on Microbiome R&D and Biostimulants & 3^rd International Conference on Internal Medicine & Hospital Medicine

October 15-16, 2018 Ottawa, Canada

Gulay Buyukkoroglu

Anadolu University, Turkey

Posters & Accepted Abstracts: Health Care Current Reviews

Abstract:

Poly(hydroxyalkanoates) (PHA) are FDA approved, non-cytotoxic, highly biocompatible and biodegradable polymers. PHAs which are the polyesters of various hydroxyalkanoate monomers which accumulate as energy/carbon storage materials in the form of granular inclusions in the cytoplasm of various bacterial cells, usually under unbalanced growth conditions. These polymers are potential candidates as carriers in drug delivery systems due to their unique and interesting features. Surface erosion of the polymers during degradation which leads to the controlled release of the active ingredient rather than burst release. The degradation rate of delivery systems can be tailored depending on the PHA used and the processing conditions. The degradation products are natural metabolites which are much less acidic than lactic acid/glycolic acid produced during degradation of other polymers such as of polylactic acid (PLA) or poly(lactic-co-glycolic ) acid (PLGA), and hence completely non-toxic and the rate of degradation is much slower than PLA/PLGA leading to long-term drug delivery. These biodegradable polymers containing an entrapped drug can be placed in the body, and they are used for localized drug delivery accompanied with the controlled release of a drug over a period of months. PHAs can also be turned into films, porous matrices, microcapsules, microspheres, and nanoparticles because of their biocompatible and hydrophobic properties and hence drugs can be entrapped or microencapsulated into their homopolymer or copolymer structure. Microsphere- or microcapsule-based PHA delivery systems have been extensively used for the delivery of a number of drugs such as anesthetics, antibiotics, anti-inflammatory agents, anticancer agents, hormones, steroids, and vaccines.

Biography :

E-mail: gbuyukko@anadolu.edu.tr