Journal of Blood Disorders & Transfusion

Prevalence of bleeding disorders in women with menorrhagia

5^th World Hematologists Congress

August 18-19, 2016 London, UK

Rashmi Kushwaha

King Georg�??s Medical University, India

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Menorrhagia is a common problem in women of reproductive age group and 5% of women between 30 and 49 years of age group consult their general practitioner for this problem. The etiology can be local or systemic disorders but a specific cause is identified in less than 50% of the cases and dysfunctional uterine bleeding is diagnosed. Menstruation is an important haemostatic challenge in women with bleeding disorders. Most of these women present with puberty onset menorrhagia. Bleeding disorders like von Willebrand Disease, single coagulation factor deficiencies particularly factor XI, VIII, Factor V and platelet function disorders like Glanzmanns disease, Bernard Soulier�??s have been found to be prevalent in patients presenting with menorrhagia. Hence, clinicians should be alert in women with menorrhagia. History taking should include: History of epistaxis, easy bruising, prolonged bleeding after tooth extraction, prolonged bleeding after any injury, bleeding in the oral cavity, GIT or any other internal organ and excessive post surgical bleeding. All the patients should be subjected to screening investigations which include bleeding time, activated partial thromboplastin time, prothrombin time and complete blood count including peripheral smear evaluation for platelet morphology. Based on the results of screening investigations, confirmatory tests like specific factor evaluation (Coagulation factors II, V, VII, VIII, IX, X, XI and XII), von Willebrand factor antigen estimation by ELISA, von Willebrand Ristocetin cofactor essay (VWF:Rco), platelet function studies including platelet aggregation using ADP and Ristocetin can be done. Hence, adolescents with known bleeding disorders should be counseled prior to menarche and before pregnancy for the possibilities of excessive bleeding in future and should also be explained about the available treatment modalities. Bleeding disorders should be kept as one of the differentials in diagnosing patients presenting with menorrhagia.

Biography :

Email: rashmikushwaha@kgmcindia.edu