Journal of Bioequivalence & Bioavailability

Preparation and evaluation of mucoadhesive microcapsules of metoprolol

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Mohammad Zuber Ali

Posters: J Bioequiv Availab

Abstract:

S ustained release alginate Microcapsules of Metoprolol were prepared by orifice-ionic-gelation method using hydroxypropyl methyl cellulose (50 cps and K4M) as mucoadhesive polymer. Microcapsules were discrete spherical and free flowing. Encapsulation efficiency varied from 45% - 65%. Microcapsules were evaluated for % yield, dry content uniformity, particle size distribution, surface morphology (scanning electron microscopy), short-term stability (at 40 + 1?C for 3 weeks) and dry- excipient interactions (IR spectroscopy). The formulation prepared by using alginate ? hydroxyl propyl methyl cellusole (K4M) in a ratio of 5 : 1 along with 4% magnesium sterate, emerged as the overall best formulation (t 50% = 2.25h, t 70% = 4.30h, t 90% = 7.58h), based on dry release characteristics (in pH 6.2 phosphate buffer). This formulation shows slow release up to 8 hrs. All the microcapsules exhibited good mucoadhesive property in the in vitro wash-off test. Short term stability studies on the promising formulations (40 + 1?C for 3 weeks) indicated that there are no significant changes in drug content and dissolution parameters (P < 0.05).