Health Care : Current Reviews

Pre-induction cervical ripening in patients with term pregnancy using oral and vaginal isosorbide dinitrate: A randomized clinical trial

3^rd Indo-Global Summit & Expo on Healthcare

October 05-07, 2015 New Delhi, India

Somayeh Moukhah and Firoozeh Ahmadi

Academic Center for Education, Iran

Posters-Accepted Abstracts: Health Care: Current Reviews

Abstract:

Background: Cervical ripening for labor is one of the most important issues in midwifery. Isosorbide dinitrate (ISDN) is one of the most important alternatives, which has been proposed for cervical ripening, but there are still controversies regarding its prescription. The present study aimed to evaluate the effects of vaginal and oral ISDN for pre-induction cervical ripening. Materials & Methods: In this non-blinded clinical trial, 99 nulliparous women with term or prolonged pregnancy were randomly selected and were divided into two groups by block randomization. The intervention groups included vaginal ISDN group (50 subjects, 40 mg, daily) and oral ISDN group (49 subjects, 20 mg, twice daily). The amount of ripening was measured by bishop score before taking medication and 24 hours after it. Results: After 24 hours, bishop score in vaginal ISDN group significantly increased compared to the oral ISDN group and the control group (P<0.001). Both of two groups were matched regarding the pregnancy termination and cesarean causes and there was no statistically significant difference between the two groups (P>0.05). Duration of induction to the second phase of delivery was compared in two groups. Although there was no statistically significant difference between the two groups in duration from the active phase to delivery and duration of the second phase (P>0.05), there was a meaningful significance difference between two groups in duration from induction to the active phase of delivery (P<0.001) and duration from induction to the active phase of delivery in vaginal ISDN group was shorter than oral ISDN group (3.7 hour versus 4.8 hour). Conclusions: Prescribing vaginal ISDN for cervical ripening was effective and can be used with confident.

Biography :

Email: so.moukhah@gmail.com