Journal of Bacteriology & Parasitology

Plasmodium yoelii infection inhibited murine leukemia WEHI-3 cells by promotion of immune responses in vivo

International Conference on Parasitology

August 24-26, 2015 Philadelphia, USA

Yong-long Li, Zheng-Zheng Tong, Pei-Li Gong and Ting Wang

Huazhong University of Science and Technology, China

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Leukemia is a malignancy disorder in leukocytes which occurs in animals as well as human. Current therapeutic for the disease remains unsatisfactory and fatality percentage is higher. Developing new therapeutic strategies for the disease is needed. It has been reported that malaria parasite infection is efficacious to combat some cancers in experimental animals. In the present paper, we studied anti-leukemia activity of malaria parasite Plasmodium yoelii infection in leukemia WEHI- 3 cells bearing mice and found that P. yoelii infection significantly inhibited the development of leukemia WEHI-3 cells in the mice and the neoplasm cells infiltrations in the liver and spleen were obviously reduced. Also, we demonstrated that malaria infection provided anti-leukemia activity by promotion of immune responses which included increasing percentages cell surface markers of T cell (CD3e) and B cell (CD19), decreasing the amount of the percentage of the cell surface markers of monocytes, (CD11b) and macrophages (Mac-3), inducing the secretion of IFN-r and TNF-α and promotion of natural killer (NK) cell activity.

Biography :

Yong-long Li graduated from Tongji Medical College in 1969. He was the Director of the Department of Parasitolgy at Tongji Medical College. He has published more than 75 papers in reputed journals and has been serving as Editorial Bord Members of journals in China.

Email: lylong@mails.tjmu.edu.cn