Journal of Bioequivalence & Bioavailability

Pharmacokinetics of glimepiride fast dissolving colon targeted pellets: A chronotherapeutic approach

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Vinay Pandit, Roopa S Pai1, Kshama Devi, Gurinder Singh and Sarasija Suresh

Posters: J Bioequiv Availab

Abstract:

The present work was conceded with an objective to delay the release of insulin secretagogue viz., glimepiride and to study its in- vitro/in- vivo behavior in colon. The pellets of glimepiride were prepared by extrusion spheronization technique using potato starch as base and PVPK 30 as binder solution. The pellets were coated with Eudragit S100 and Eudragit L100 in order to provide delayed release of drug in colon. The prepared pellets were evaluated for drug content, friability, particle size analysis, in-vitro disintegration time, in-vitro drug release studies and in-vivo behavior. The pellets were evaluated by differential scannning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) to study the stability of drug in the carrier system. The in vitro release studies of developed pellets indicated the delayed release as there was no release till 5 hours of the study. The results were statistically analyzed by one way ANOVA followed by tukey post hoc test for multiple comparison. The pharmacokinetic studies revealed that the Tmax of formulated pellets was 8 hr where as for the pure drug it was 4 hrs indicating pellet release in colon. In conclusion, the starch pellets of glimepiride coated with Eudragits were prepared successfully and can be beneficial for chronotherapy of diabetes.