Dentistry

Periodontal wound healing/regeneration: Biological directives for clinical success

19^th American Dental Congress

December 08-10, 2016 Phoenix, USA

Ulf Me Wikesjo

Augusta University, Georgia

Posters & Accepted Abstracts: Dentistry

Abstract:

Current clinical protocol aimed that periodontal regeneration meets limited success. The procedures are unpredictable, or, with few exceptions, results in only incremental improvements. Limited treatment outcomes may result from incomplete understanding of biologic processes critical to periodontal wound healing/regeneration. Our laboratory for Applied Periodontal & Craniofacial Regeneration has developed discriminating preclinical models to evaluate the biology of periodontal wound healing/regeneration and to evaluate the efficacy and safety of candidate biomaterials, devices and biologic factors intended for periodontal regeneration prior to clinical introduction. We have evaluated occlusive and novel macro-porous devices for guided tissue regeneration (GTR), various bone biomaterials and growth factors including rhBMP-2 and rhGDF-5 in advanced periodontal defects. This presentation will discuss biologic requirements for successful periodontal regenerative procedures. This presentation will also discuss background and biologic potential of current treatment concepts including GTR, bone biomaterials and candidate growth factors as stand-alone protocols or in combination. Our studies suggest that wound stability during the early phase of healing will allow maturation of the tooth gingival flap interface into a new connective tissue rather than formation of an epithelial attachment (long junctional epithelium). Root conditioning and/or surgical implantation of growth factors, bone biomaterials and devices for GTR may dramatically alter the outcomes of healing for better or worse.

Biography :

Email: UWIKESJO@augusta.edu