Journal of Bioequivalence & Bioavailability

Optimization of solid lipid nanoparticles prepared by microemulsion dilution for microencapsulation of bioactive compounds from red cabbage

6^th World Congress on Bioavailability & Bioequivalence: BA/BE Studies Summit

August 17-19, 2015 Chicago, USA

R Ravanfar1,2, A M Tamaddon3, M Niakousari2 and M R Moein3

Posters-Accepted Abstracts: J Bioequiv Availab

Abstract:

Anthocyanins are the main polyphenol components in extract of fresh red cabbage (Brassica oleracea) with inherent antioxidant
activity. To protect them against harsh environmental conditions (e.g. pH and temperature), solid lipid nanoparticles
were prepared by dilution of w/o microemulsion containing anthocyanins, in aqueous media. The formulations were characterized
regarding particle size and encapsulation efficiency. The formulation parameters (e.g. % total lipid, volume of internal aqueous phase,
homogenization time, % total surfactant, % stabilizer) were optimized by Placket-Burman and Box-Behnken experimental designs.
The highest value of EE (89%) was obtained when mean particle size was 6 microns and the lowest particle size (417 nm) was achieved
while EE value was 35.8%. SEM study revealed a spherical morphology of the particles.