Journal of Bioequivalence & Bioavailability

Optimization of Aceclofenac proniosomes by using mannitol as a carrier

10^th World Congress on Bioavailability and Bioequivalence

April 08-09, 2019 Abu Dhabi, UAE

Rana Mhd Farid Sammour, Muhammad Taher, Bappaditya Chatterjee and Aliasgar Shahiwala

International Islamic University of Malaysia, Malaysia
Dubai Pharmacy College for Girls, UAE

Scientific Tracks Abstracts: J Bioequiv Availab

Abstract:

Aim is to optimize a free-flowing and stable proniosome formulation of Aceclofenac that is considered as a poorly water-soluble drug by using mannitol as a carrier. Slurry method were used for the preparation of the proniosomes by using span60, cholesterol, mannitol and Aceclofenac as a drug. Different characterization were done for the prepared proniosomes such as DSC, FTIR and flowability. While Entrapment Efficiency and Zetapotential with Zetasizer were done for the niosomes derived from Aceclofenac proniosomes after hydration. In vitro drug released were studied by using the diffusion membrane technique and percentage of drug release were analyzed by using HPLC method. The proniosomal powder were compatible and exhibited excellent flowability. The niosomes derived from

Biography :

Rana Mhd Farid Sammouris lecturer in Pharmaceutics Department at Dubai Pharmacy College, UAE. She has completed her Master of Science in Pharmacy ( Msc Pharm ) in Pharmaceutical Technology from Ajman University , Ajman, UAE and Bachelor (Honor) in Pharmacy from Dubai Pharmacy College, UAE.

E-mail: ranasammor81@hotmail.com