Journal of Allergy & Therapy

Novel drug eluting nasal stents â?? our experience

9^th International Conference on Otology, Rhinology and Laryngology

November 10, 2023 | Webinar

Amulya Manohar Thotambailu

JSS Medical College, India

Scientific Tracks Abstracts: J Allergy Ther

Abstract:

Introduction: A novel approach to the treatment of sinusitis is the use of nasal stents. The stent is loaded with a corticosteroid, which prevents complications in the woundhealing process. The design is such that it will prevent the sinus from closing again. Materials and methods: The stent is 3D printed using a fused deposition modeling printer, which enhances the customization. The polymer utilized for the purpose of 3D printing is polylactic acid (PLA). The compatibility between the drugs and polymers is confirmed by FT-IR and DSC. The drug is loaded onto the polymer by soaking the stent in the drug’s solvent, known as the solvent casting method Results: Using this method, approximately 68% of drug loading is found to be achieved onto the PLA filaments, and a total of 72.8% of drug loading is obtained in terms of the 3D-printed stent. Drug loading is confirmed by the morphological characteristics of the stent by SEM, where the loaded drug is clearly visible as white specks on the surface of the stent. Drug release characterization is conducted by dissolution studies, which also confirm drug loading. The dissolution studies show that the release of drugs from the stent is constant and not erratic. Biodegradation studies were conducted after increasing the rate of degradation of PLA by soaking it in PBS for a predetermined duration of time Discussion: The mechanical properties of the stent, such as stress factor and maximum displacement, are discussed. The stent has a hairpin-like mechanism for opening inside the nasal cavity. Keywords: Sinusitis; nasal stents; 3D printed nasal stents; Endoscopic sinus surgery; Biomaterials; Biomaterials in 3D printing.

Biography :

Amulya Manohar Thotambailu is an Otorhinolaryngology by profession, a teacher by passion & researcher by interest. Completed her MS (ENT) from the NITTE University in 2017. She has been a proud recipient of the ` Hazarika travel fellowship` during post-graduation. Amulya Manohar trained in Rhinology under Dr Narayanan Janakiram following postgraduation. She has been involved in departmental and interdepartmental research activities. She received Laryngology fellowship in 2019 during AOIKCON 2019.Recently I received the MAHE FAIMER Fellowship 2021. She also in charge of the Dysphagia Clinic of ENT department. She also NABH coordinator of her respected department. She also a member of the COVID TASK FORCE Team in hospital. she also a member of Breath Healthy Clinic at our hospital. Areas of interest are Allergy, functional endoscopic sinus surgery, sleep medicine, laryngology.