Health Care : Current Reviews

Natureâ??s blueprint for regeneration: Herbal biomolecules in stem cell based periodontal therapy

35^th Global Healthcare Summit

January 27-28, 2025 Webinar

Amer Anil Zope

Krishna Vishwa Vidyapeeth, India

Scientific Tracks Abstracts: Health Care Curr Re

Abstract:

Periodontal disease, a major cause of tooth loss globally, presents significant challenges to tissue regeneration due to the structural complexity of the periodontium, encompassing the periodontal ligament, alveolar bone, and cementum. Traditional regenerative treatments frequently fall short of fully restoring these specialized tissues. Stem cell-based therapies have emerged as promising alternatives, particularly when integrated with bioactive compounds from medicinal plants. This review explores the role of herbal biomolecules as adjuncts in stem cell-based periodontal therapy, highlighting their potential to enhance cell proliferation, differentiation, and migration—key processes required for effective tissue regeneration. Herbal biomolecules, rich in antioxidants and anti-inflammatory agents, have shown promise in supporting periodontal regeneration by promoting the activity of resident stem cells. Notable examples include the immunomodulatory effects of curcumin (*Curcuma longa*), which can reduce inflammation while stimulating tissue repair, and catechins from green tea (*Camellia sinensis*), which have demonstrated proliferationinducing properties in periodontal tissues. These biomolecules also support angiogenesis and extracellular matrix remodeling, critical for sustainable tissue integration and function. The application of herbal biomolecules in combination with advanced cell delivery systems, such as hydrogels and scaffolds, offers controlled, localized release that maximizes their bioactivity and targets periodontal defects. These bioengineered approaches create a conducive microenvironment that mimics natural tissue repair processes, thus enhancing stem cell efficacy and promoting faster, more predictable healing. Through a biomimetic approach, leveraging both natural compounds and advanced cell-based techniques, periodontal regeneration can achieve more precise outcomes with enhanced biocompatibility. There is the need for further clinical research to optimize the therapeutic concentration, delivery mechanisms, and long-term effects of herbal biomolecules in periodontal regeneration. Harnessing the regenerative potential of nature through stem cell-based therapies holds promise to revolutionize periodontal treatment, making it safer, more effective, and widely accessible for patients suffering from periodontal disease.

Biography :

Ameer Anil Zope is an esteemed Associate Professor of Periodontology at the School of Dental Sciences, Krishna Vishwa Vidyapeeth, Karad. With a distinguished academic and clinical career, He is widely recognized for his contributions to dental research, having published extensively in leading journals and presented at renowned international conferences. His accolades include the "Outstanding Periodontist of the Year 2022" award and the "Young Faculty 2020" recognition. A passionate educator, he plays an active role in academic and professional development, and has authored multiple books and chapters in periodontology. Additionally, He holds several patents, further demonstrating his innovative contributions to the field. A respected member of various dental associations, he also serves on the editorial boards of esteemed scientific journals, reaffirming his dedication to advancing dental science and education.