Clinical & Medical Biochemistry

Natural source of origin to treat hyper proliferated skin cells disease like psoriasis by nanoencapsulatled drug delivery systems

14^th International Conference on Biosimilars and Pharma Innovations

November 09, 2022 | Webinar

Narendra Pentu

CMR College of Pharmacy, India

Posters & Accepted Abstracts: Clin Med Bio Chem

Abstract:

Encapsulated drug delivery systems are site specific and targeting approach to treat carcinogenic cells. Continuous proliferation of cells is the basic symptom in Psoriasis disease. In psoriasis disease keratin cells present in skin layers are become hyper profilarative in disease condition and requires regular attention to treat skin layer cells by without damaging. Topical therapy is the best attentive treatment to treat and modify the damaged skin layers, as this disease requires long term therapy to treat skin cells. When drugs are from natural source like flavonoids having activities like Anti-inflammatory, Anti Proliferative activity to treat Psoriasis. Flavonoid class of drugs when it is given in Nano encapsulated form for topical use, these drug compounds are best accumulated in skin layers and encounter the serial actions of inflammatory responses. Targeting approach of the Nano encapsulated drug delivery is completely utilized when it is deliver through the topical route to treat Psoriasis. Psoriasis is an auto immune disease, in this T- cells are initiated to attack on our body cells and continuously trigger the inflammatory signals to release Alpha- necrosis factors. This serial incidents in inflammatory responses may cause continuous itching of skin cells and leads to hyper proliferation of Keratinized skin cells. This may cause deposit of skin cells on skin layers in various parts of our body. Nano encapsulated systems are best suitable therapy to treat Hyper proliferation of cells like in cancer cells. If this treatment is done through the topical encapsulated form, drug accumulation in the skin layers is more when comparing to other therapies. Permeation of drug through skin layers is more comfortable when it is given in encapsulated form. The major barrier in Topical therapy is to cross the stratumcornium skin layer that can be achieved by through the Nano encapsulated systems. So, future scope is in the treatment of Psoriasis is Nano encapsulated systems with natural source of origin drug delivery.