Journal of Blood Disorders & Transfusion

Myocardial infarction caused by triple-hit lymphoma

11^th International Conference on Hematology & Hematological Oncology

November 08-09, 2017 | Las Vegas, USA

Hermon Amanuel and Pavel P Kotoucek

Darent Valley Hospital, UK

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Triple Hit Lymphoma (THL) is an extremely rare and aggressive form of Non-Hodgkin lymphoma with morphologic, phenotypic and genetic features of both diffuse large B cell lymphoma (DLBCL) and Burkitt Lymphoma (BL). Its characteristic cytogenetic abnormalities involve chromosomal rearrangements of c-MYC, BCL-2 and BCL-6 genes. It has been recognized, in the 2016-revised WHO classification of lymphoid neoplasms, as High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements. We describe a case of a 68 years old male with two years history of stable low-grade follicular lymphoma suddenly transforming into acute leukemia caused by THL. During the aggressively progressive phase, he developed Non-ST Elevation MI (NSTEMI), diagnosed by raised troponin and new anterolateral ST depressions on his ECG. His MI was attributed to leukostasis, anemia and coagulopathy. THL carries the poorer prognosis than either DLBCL or BL alone; thus it should be recognized as hematological emergency and patient with such diagnosis should be managed in high dependence unit were possible.

Biography :

Hermon Amanuel has completed her Medical degree training at King’s Collage London, UK. She is currently undergoing training as Core Medical Trainee at Kent, Surrey and Sussex Deanery.