Journal of Clinical Research & Bioethics

MicroRNA expression pattern in the context of translational research and as tool for cancer patient stratification

6^th International Conference on Advanced Clinical Research and Clinical Trials

September 10-11, 2018 | Zurich, Switzerland

J C Hahne

The Institute of Cancer Research, UK

Keynote: J Clin Res Bioeth

Abstract:

MicroRNAs are pivotal regulators for RNA silencing and post-transcriptional regulation of gene expression under physiological as well as pathological conditions. MicroRNAs can be detected in tissues and in most biologic fluids including serum, plasma and urines. Secreted microRNAs are either incorporated into micro-vesicles or circulate bound to proteins. In both cases microRNAs are protected from RNase degradation so that they may remain intact for long periods of time. Therefore they might represent potential new biomarkers. We analysed expression of 800 miRNAs using nCounter Nanostring technology in cancer cell lines, formalin fixed paraffin embedded tissues and plasma from cancer patients. Potential clinical applications of microRNA detection for cancer patients??? management will be discussed.

Biography :

J C Hahne received his PhD in Biochemistry from the Albert-Ludwigs-University Freiburg i.Br. (Germany). During several Postdoc positions in Department of Molecular Pathology at the University of Bonn, Germany; Charite Berlin, Germany; Department of Gynaecology and Obstetrics at the University of Wuerzburg, Germany, he received a broad training and knowledge in molecular pathology and cancer research. At the moment he is working in the Department of Molecular Pathology at the ICR (London, UK). He has published more than 70 papers in reputed journals and has been serving as an Editorial Board Member of repute.

E-mail: jens.hahne@icr.ac.uk