Brain Disorders & Therapy

KI induced effects extend beyond kidneys and affect many systems including the brain where it has been associated with encephalopathy

International Conference on Neuro Oncology and Rehabilitation

July 21-22, 2016 Brisbane, Australia

Ali Ayman Mowafy

Mansoura University, Egypt

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Ischemic Acute Kidney Injury (AKI) has many consequences that affect the development of chronic kidney disease following ischemia; kidney�??s tissues are exposed to a reperfusion phase, where damage is caused by inflammatory mediators released following resolution of the ischemia. Accentuation of innate immunity during ischemia reperfusion injury (IRI) seems to be affected by toll like receptors, especially TLR-2 and TLR4. It has been demonstrated that AKI induced effects extend beyond kidneys and affect many systems including the brain where it has been associated with encephalopathy. Animal experiments have shown that AKI leads to inflammation within the hippocampal region which was confirmed by Liu et al., who observed an increased number of activated microglia in the hippocampus of rats with AKI, which may account for a state of uremic encephalopathy. In a previous study at Medical Experimental Research Center (MERC), Salama et al., found that TLR-4 was up regulated in AKI group compared to the sham group as evident by increase the density of TLR-4 in the hippocampus and striatum in parallel to increase in microglia in the same regions as previously reported by Liu et al. The finding confirms the triggering effect of TLR-4 on AKI induced neuroinflammation that possibly leads to AKI induced encephalopathy. Our new hypothesis states that TLR-4 receptor blocker may have a role in preventing AKI effects on the brain.an experimental trial conducted by our research team.

Biography :

Email: alimowafy2010@gmail.com