Journal of Psychiatry

Incidence, etiology and risk factors of post-stroke depression in patients with acute ischemic stroke: A prospective study in Taiwan

2^nd International Conference on Psychiatry and Psychiatric Disorders

May 02-04, 2016 Chicago, Illinois, USA

Jian-An Su

Chiayi Chang Gung Memorial Hospital, Taiwan

Posters & Accepted Abstracts: J Psychiatry

Abstract:

Background: Post-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke and the influence is devastating. Our study aimed to determine the etiology, incidence and risk factors for the development of PSD. Methods: Patients with ischemic stroke admitted to a general teaching hospital were enrolled in this six-month study. The patients were evaluated with the Toronto Alexithymia Scale-20 (TAS-20), Beck Anxiety Inventory (BAI), National Institute of Health Stroke Scale (NIHHS) and Mini-Mental Status Examination (MMSE) at baseline and then followed up each month for detection of PSD using the Center for Epidemiologic Studies of Depression (CES-D) scale. Cytokines such as interleukin-1, interlukin-6, tumor necrosis factor-α and interferon-γ were checked as well while in PSD and compared with the data in baseline. Results: In all, 285 patients with ischemic stroke were enrolled, and 93.3% completed the 6-month study. The overall incidence of PSD within six months was 16.5%. In multi-variate regression analyses, the incidence of PSD was significantly associated with higher BAI, higher NIHSS and higher TAS-20 scores. There were significant increases in the cytokines interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor α (TNF-α) and interferon-γ and the ratios of IL-6/IL-10 and TNF-α/IL-10 were also elevated in patients with PSD. Conclusion: This is the first study to address the significant relationship between alexithymia and PSD. It also suggested that immune imbalance plays a possible role in the patho physiology of PSD and that IL-6 and TNF-α are key cytokines. Clinical professionals should pay more attention to stroke patients with alexithymic features and other risk factors.

Biography :

Email: jian.7715@gmail.com